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Sitting-induced Endothelial Dysfunction Is Prevented in Endurance-trained Individuals


Med Sci Sports Exerc. 2020

Sitting-induced Endothelial Dysfunction Is Prevented in Endurance-trained Individuals.

Morishima T1, Tsuchiya Y2, Ueda H3, Tsuji K4, Ochi E1,4,5.

Author information

1 Sports Research Center, Hosei University, Tokyo, Japan.

2 Faculty of Modern Life, Teikyo Heisei University, Tokyo, Japan.

3 Faculty of Health and Medical Science, Teikyo Heisei University, Chiba, Japan.

4 Center for Public Health Science, National Cancer Center, Tokyo, Japan.

5 Faculty of Bioscience and Applied Chemistry, Hosei University, Tokyo, Japan.

Abstract

PURPOSE:

Prolonged sitting impairs leg endothelial function, which seems to be mediated by a sustained reduction in blood flow-induced shear stress. However, whether regular endurance training is effective in preventing sitting-induced leg endothelial dysfunction remains largely unknown. Herein, we tested the hypothesis that sitting-induced leg endothelial dysfunction is prevented in high endurance-trained individuals.

METHODS:

The endurance-trained group comprised 10 male collegiate cyclists, and the untrained group comprised 9 male with no regular endurance training. Peak oxygen uptake (VO2peak) was initially determined in all participants using incremental exercise test (37.9 ± 4.7 mL/min/kg in the untrained group vs. 60.8 ± 3.6 mL/min/kg in the endurance-trained group). At second visit, the popliteal artery flow-mediated dilation (%FMD) was assessed before and after a 3-h sitting period. During the sitting period, the popliteal artery diameter and blood velocity were measured every hour.

RESULTS:

The popliteal artery blood flow and shear rate were significantly and similarly reduced during the sitting period in both groups (P < 0.001). In a 3-h sitting, a significant impairment in popliteal artery %FMD was observed in the untrained group (P = 0.003), but it was prevented in the endurance-trained group (P < 0.196).

CONCLUSION:

In conclusion, the present study revealed that sitting-induced leg endothelial dysfunction is preventable in endurance-trained individuals.






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