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Biomedicines. 2026 Jul 23;14(8):1654. doi: 10.3390/biomedicines14081654. I-Min Su, Shih-Yuan Ye, Jer-Chuan Li, Du-An Wu, Bang-Gee Hsu Abstract Background/Objectives: Endothelial dysfunction represents an early stage of vascular injury in type 2 diabetes mellitus (T2DM) and contributes to increased cardiovascular risk. Leptin, a hormone involved in metabolic and inflammatory regulation, has been implicated in vascular dysfunction. However, its association with digital thermal

Eur J Appl Physiol. 2026 Jul 3. doi: 10.1007/s00421-026-06335-1. Rian Q Landers-Ramos, Olivia C Zakrewski Abstract Introduction: The presence of sex differences in various vascular assessments in younger to middle-aged adults is inconsistent in the literature. Purpose: Determine whether sex differences are present across four different indices of vascular health. Methods: Healthy, recreationally active premenopausal females (N = 30) and similarly aged males (N = 30) aged 18-

Front Cardiovasc Med. 2026 Jun 12:13:1828504. doi: 10.3389/fcvm.2026.1828504.eCollection 2026. Ji-Hung Wang, I-Min Su, Bang-Gee Hsu Abstract Objective: Endothelial dysfunction is a key mechanism in the progression of coronary artery disease (CAD). N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), a biomarker of myocardial wall stress, has been associated with vascular abnormalities beyond overt heart failure. However, its relationship with endothelial function, as asses

Medicina (Kaunas). 2026 May 24;62(6):1018. doi: 10.3390/medicina62061018. Po-Yu Huang, Min-Han Hsieh, Ji-Hung Wang, Jen-Pi Tsai, Bang-Gee Hsu Abstract Background and Objectives: Endothelial dysfunction is essential in the development and progression of coronary artery disease (CAD) and its complications. Galectin-3 mediates inflammation and organ fibrosis and promotes endothelial dysfunction. Meanwhile, the vascular reactivity index (VRI) reflects endothelial function. The p

Life (Basel) . 2026 May 8;16(5):787. doi: 10.3390/life16050787. I-Min Su, Bang-Gee Hsu, Chin-Hung Liu , Ho-Hsiang Chang, Ming-Chun Chen Abstract p-Cresyl sulfate (PCS) is associated with endothelial injury and adverse cardiovascular outcomes. However, its association with endothelial function in patients on peritoneal dialysis (PD) remains unclear. In this cross-sectional study, 82 patients receiving PD were enrolled. Serum PCS concentrations were quantified using high-perfo

Tzu Chi Med J 2026 Jan 12;38(2):203-209. doi: 10.4103/tcmj.tcmj_173_25. eCollection 2026 Apr-Jun. Teoh Ling Lun, Yu-Li Lin, Chih-Hsien Wang, Yu-Hsien Lai, Chiu-Huang Kuo, Chi-Chong Tang, Bang-Gee Hsu Abstract Objectives: Adipocyte fatty acid-binding protein (A-FABP) has been implicated in atherosclerosis, and endothelial dysfunction is a critical contributor to cardiovascular outcomes in chronic kidney disease (CKD). This study evaluated links between serum A-FABP and endot

Am J Physiol Heart Circ Physiol. 2026 Apr 1;330(4):H1065-H1072. doi: 10.1152/ajpheart.00706.2025.Epub 2026 Jan 17. Salma Charfeddine, Mohamed Ali Hbaieb, Niez Laribi, Mariem Jabeur, Amine Bahloul, Marwa Jarraya, Hassen Gargouri, Aiman Ghrab, Zied Triki, Tarek Ellouze, Faten Triki, Rania Gargouri, Leila Abid Abstract Endothelial function, a key determinant of prognosis in heart failure with reduced ejection fraction (HFrEF), is still frequently under-assessed in clinical prac

Am J Physiol Heart Circ Physiol 2026 Apr 1;330(4):H1235-H1238. doi: 10.1152/ajpheart.00980.2025.Epub 2025 Dec 31. Molly K Courish , Myles W O'Brien INTRODUCTION Chronic heart failure involves functional and structural impairment of ventricular filling or ejection of blood from the ventricles, with ∼50% of cases being heart failure with reduced ejection fraction (HFrEF) (1). Systemic vascular dysfunction has been identified as a key factor in the pathogenesis and progression

Abstract Cardiovascular disease (CVD) is a leading cause of mortality in men with prostate cancer (PC), with non‐Hispanic Black (NHB) men experiencing disproportionately higher CVD‐related mortality compared to non‐Hispanic White (NHW) men. Vascular endothelial dysfunction precedes overt CVD; however, the mechanisms underlying racial disparities in CVD among men with PC remain unclear. This study tested the hypothesis that NHB men with PC would exhibit impaired vascular healt

Cardiovasc Ultrasound .2026 Jan 12;24(1):2 Mengjiao Li , Yingying Huang , Linghui Bai , Wei Li , Chenbo Chu , Hui Liu Abstract Background: Coronary microvascular disease (CMVD) is a major cause of hospitalization for a considerable number of patients with ischemia with non-obstructive coronary arteries (INOCA), with coronary flow reserve (CFR) reduction being the main feature of CMVD. However, imaging methods for CMVD evaluation are still lacking. This study aimed to i

I-Min Su , Li-Liang Chuang , Ji-Hung Wang , Bang-Gee Hsu Medicina (Kaunas).2025 Nov 28;61(12):2132. Abstract Background and Objectives : Endothelial dysfunction represents an early indicator of cardiovascular disease in individuals with hypertension. Leptin, an adipokine that regulates vascular homeostasis and metabolism, has been linked to vascular impairment; however, its relationship with vascular reactivity in hypertensive patients remains unclear. Materials and Met

Bang-Gee Hsu, Yi-Cheng Wang, Du-An Wu, Ming-Chun Chen Abstract Circulating 25-hydroxyvitamin D (25(OH)D) significantly influences endothelial function. This study assessed the correlation between serum 25(OH)D and endothelial function using the vascular reactivity index (VRI) in patients with type 2 diabetes mellitus (T2DM). Fasting blood samples from 102 T2DM participants and VRI were assessed. Patients were divided into three categories based on VRI: low (VRI < 1.0), interm

Ren Fail.2025 Dec;47(1):2581940. Wen-Lin Lo , Bang-Gee Hsu , Chih-Hsien Wang , Yu-Lin Lin , Chiu-Huang Kuo , Yu-Hsien Lai Abstract Background: Patients with maintenance hemodialysis (MHD) present endothelial dysfunction (ED), which is characterized by impaired vasodilation and a pro-inflammatory state. Lipoprotein(a) (Lp(a)) has pro-inflammatory and pro-atherogenic properties. No study has investigated the association between serum Lp(a) and ED in patients with MHD. T

Diagnostics (Basel). 2025 Sep 20;15(18):2400. I-Min Su , Ji-Hung Wang , Chin-Hung Liu , Bang-Gee Hsu Abstract Background/Objectives : Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite influenced by diet, has been linked to cardiovascular disease. Endothelial dysfunction, an early sign of vascular damage, is common in hypertension. This study examined the relationship between serum TMAO levels and endothelial function, assessed by the vascular reactivity

JAMA Cardiol.2025 Aug 1;10(8):851-855. Leila Mohammadi, Mina Navabzadeh, Nerea Jiménez-Téllez, Daniel D Han, Emma Reagan, Jordan...

PLoS One. 2025 Jun 5;20(6):e0324945. Dariya Kozlova , Colin Gimblet , Linder Wendt , Sadaf Akbari , Adeyinka Taiwo , Sanjana Dayal...

Raymond Rubianto Tjandrawinata , Isabela Caiado Caixeta Vencio , Axel Brahmantyo Maynardo Nugroho Jonathan Hartanto , Nicolas Daniel...

Inderjeet Singh Bharaj , Ajit Singh Brar , Jasraj Kahlon , Anmol Singh , Priya Hotwani , Vikash Kumar , Aalam Sohal , Akash Batta...

Pulmonary hypertension (PH) and atrial fibrillation (AF) are more than just coexisting conditions—they’re interconnected through a complex web of shared molecular mechanisms and risk factors. A new comprehensive review explores how endothelial dysfunction, inflammation, oxidative stress, and other cellular processes drive this dangerous duo, contributing to poor outcomes and limited treatment options.

Impairments in NVC of the frontal cortex may be an early cerebrovascular mechanism underpinning cognitive decline in MetS and is discernible during higher cognitive loads. Peripheral endothelial dysfunction may be implicated in this mechanism.