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How Does VENDYS Work?
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Relationship between epicardial fat tissue, endothelial function, and coronary flow reserve in coronary microvascular disease patients
Cardiovasc Ultrasound .2026 Jan 12;24(1):2 Mengjiao Li , Yingying Huang , Linghui Bai , Wei Li , Chenbo Chu , Hui Liu Abstract Background: Coronary microvascular disease (CMVD) is a major cause of hospitalization for a considerable number of patients with ischemia with non-obstructive coronary arteries (INOCA), with coronary flow reserve (CFR) reduction being the main feature of CMVD. However, imaging methods for CMVD evaluation are still lacking. This study aimed to i


Hyperleptinemia Is a Risk Factor for the Development of Vascular Reactivity Impairment in Patients with Hypertension
I-Min Su , Li-Liang Chuang , Ji-Hung Wang , Bang-Gee Hsu Medicina (Kaunas).2025 Nov 28;61(12):2132. Abstract Background and Objectives : Endothelial dysfunction represents an early indicator of cardiovascular disease in individuals with hypertension. Leptin, an adipokine that regulates vascular homeostasis and metabolism, has been linked to vascular impairment; however, its relationship with vascular reactivity in hypertensive patients remains unclear. Materials and Met


Serum 25-Hydroxyvitamin D Level Is Positively Associated with Vascular Reactivity Index in Patients with Type 2 Diabetes Mellitus
Bang-Gee Hsu, Yi-Cheng Wang, Du-An Wu, Ming-Chun Chen Abstract Circulating 25-hydroxyvitamin D (25(OH)D) significantly influences endothelial function. This study assessed the correlation between serum 25(OH)D and endothelial function using the vascular reactivity index (VRI) in patients with type 2 diabetes mellitus (T2DM). Fasting blood samples from 102 T2DM participants and VRI were assessed. Patients were divided into three categories based on VRI: low (VRI < 1.0), interm
![Lipoprotein(a) levels predict endothelial dysfunction in maintenance hemodialysis patients: evidence from [VENDYS] vascular reactivity index assessment](https://static.wixstatic.com/media/dac531_5285607cc591409a9d83746f042af7c6~mv2.png/v1/fill/w_334,h_250,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/dac531_5285607cc591409a9d83746f042af7c6~mv2.webp)
![Lipoprotein(a) levels predict endothelial dysfunction in maintenance hemodialysis patients: evidence from [VENDYS] vascular reactivity index assessment](https://static.wixstatic.com/media/dac531_5285607cc591409a9d83746f042af7c6~mv2.png/v1/fill/w_327,h_245,fp_0.50_0.50,q_95,enc_avif,quality_auto/dac531_5285607cc591409a9d83746f042af7c6~mv2.webp)
Lipoprotein(a) levels predict endothelial dysfunction in maintenance hemodialysis patients: evidence from [VENDYS] vascular reactivity index assessment
Ren Fail.2025 Dec;47(1):2581940. Wen-Lin Lo , Bang-Gee Hsu , Chih-Hsien Wang , Yu-Lin Lin , Chiu-Huang Kuo , Yu-Hsien Lai Abstract Background: Patients with maintenance hemodialysis (MHD) present endothelial dysfunction (ED), which is characterized by impaired vasodilation and a pro-inflammatory state. Lipoprotein(a) (Lp(a)) has pro-inflammatory and pro-atherogenic properties. No study has investigated the association between serum Lp(a) and ED in patients with MHD. T


Elevated Serum Trimethylamine N-Oxide Predicts Impaired Vascular Reactivity in Patients with Hypertension
Diagnostics (Basel). 2025 Sep 20;15(18):2400. I-Min Su , Ji-Hung Wang , Chin-Hung Liu , Bang-Gee Hsu Abstract Background/Objectives : Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite influenced by diet, has been linked to cardiovascular disease. Endothelial dysfunction, an early sign of vascular damage, is common in hypertension. This study examined the relationship between serum TMAO levels and endothelial function, assessed by the vascular reactivity


Association of Endothelial Dysfunction With Chronic Marijuana Smoking and THC-Edible Use
JAMA Cardiol.2025 Aug 1;10(8):851-855. Leila Mohammadi, Mina Navabzadeh, Nerea Jiménez-Téllez, Daniel D Han, Emma Reagan, Jordan...


Vascular dysfunction is associated with major adverse cardiovascular events in prediabetes: A cohort study
PLoS One. 2025 Jun 5;20(6):e0324945. Dariya Kozlova , Colin Gimblet , Linder Wendt , Sadaf Akbari , Adeyinka Taiwo , Sanjana Dayal...


Guardians of the sea: molecular and biochemical adaptations in sharks and whales for atherosclerosis resistance and their potential in human cardioprotection
Raymond Rubianto Tjandrawinata , Isabela Caiado Caixeta Vencio , Axel Brahmantyo Maynardo Nugroho Jonathan Hartanto , Nicolas Daniel...


Metabolic-dysfunction associated steatotic liver disease and atrial fibrillation: A review of pathogenesis
Inderjeet Singh Bharaj , Ajit Singh Brar , Jasraj Kahlon , Anmol Singh , Priya Hotwani , Vikash Kumar , Aalam Sohal , Akash Batta...


The Interplay Between Pulmonary Hypertension and Atrial Fibrillation: A Comprehensive Overview
Pulmonary hypertension (PH) and atrial fibrillation (AF) are more than just coexisting conditions—they’re interconnected through a complex web of shared molecular mechanisms and risk factors. A new comprehensive review explores how endothelial dysfunction, inflammation, oxidative stress, and other cellular processes drive this dangerous duo, contributing to poor outcomes and limited treatment options.


Impaired Neurovascular Coupling in Metabolic Syndrome: An fNIRS study
Impairments in NVC of the frontal cortex may be an early cerebrovascular mechanism underpinning cognitive decline in MetS and is discernible during higher cognitive loads. Peripheral endothelial dysfunction may be implicated in this mechanism.


Targeting Mitochondrial Dysfunction to Prevent Endothelial Dysfunction and Atherosclerosis in Diabetes: Focus on the Novel Uncoupler BAM15
Woong Bi Jang, Vinoth Kumar Rethineswaran, Sang-Mo Kwon Int J Mol Sci .2025 May 11;26(10):4603. Abstract Diabetes mellitus is a chronic...


Effects of singing on vascular health in older adults with coronary artery disease: a randomized, crossover trial
The impact of singing on cardiovascular health has not been extensively studied. The aim of this study is to investigate the effect of singing on cardiovascular biomarkers in an aging population with coronary artery disease (CAD)


Exploring endothelial dysfunction in major rheumatic diseases: current trends and future directions
Arshiya S Anwar Husaini # 1 , Aseela Fathima # 1 , Dunia Halawa # 1 , Nada Aakel # 1 , Gian Luca Erre 2 3 , ...


Endothelial dysfunction in chronic obstructive pulmonary disease: an update on mechanisms, assessment tools and treatment strategies
Front Med (Lausanne) .2025 Feb 12:12:1550716 Giuseppina Marcuccio , Claudio Candia , Mauro Maniscalco , Pasquale Ambrosino Abstract...


Advances in the diagnosis and management of post-percutaneous coronary intervention coronary microvascular dysfunction: Insights into pathophysiology and metabolic risk interactions
World J Cardiol. 2025 Feb 26;17(2):103950. Nan Tang , Kang-Ming Li , Hao-Ran Li , Qing-Dui Zhang , Ji Hao , Chun-Mei Qi Abstract...


Microvascular Endothelial Dysfunction in Vascular Senescence and Disease
Oxidative stress and inflammation are inherent to vascular aging, act through the lifespan of animals, and are probably set since intrauteri


SGLT2 Inhibitors: The First Endothelial-Protector for Diabetic Nephropathy
SGLT2i have emerged as a class of agents relevant for managing diabetic nephropathy and cardiopathy.


Effects of Weight Loss on Endothelium and Vascular Homeostasis: Impact on Cardiovascular Risk
Margherita Tiezzi, Francesco Vieceli Dalla Sega, Paolo Gentileschi, Michela Campanelli, Domenico Benavoli, Elena Tremoli...


Relationship Between Serum Myostatin and Endothelial Function in Non-Dialysis Patients with Chronic Kidney Disease
Diseases .2024 Dec 13;12(12):328. Ho-Hsiang Chang , Chih-Hsien Wang , Yu-Li Lin , Chiu-Huang Kuo , Hung-Hsiang Liou , Bang-Gee Hsu...
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