VENDYS Publications
Presented at ESC'25
Naghavi, M & Messahli, L & Naghavi, Yasamin & Gul, Ahmed & Gul, M & Yen, A & Tanaka, Hirofumi & Metcalfe, R & Kleis, Stanley. (2024). Distribution of microvascular endothelial function in different clinical and non-clinical settings in the united states and china. European Heart Journal. 45. 10.1093/eurheartj/ehae666.3528.
Scientific Publications (click to view full-text)
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Wen-Lin Lo, Bang-Gee Hsu, Chih-Hsien Wang, Yu-Lin Lin, Chiu-Huang Kuo, Yu-Hsien Lai. Ren Fail.2025. Dec;47(1):2581940.
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I-Min Su, Ji-Hung Wang, Chin-Hung Liu, Bang-Gee Hsu. Diagnostics (Basel). 2025 Sep 20;15(18):2400.
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Naghavi M, Kleis S, Tanaka H, Yen AA, Zhuang R, Gul A, Naghavi Y, Metcalfe R. High Frequency of Microvascular Dysfunction in US Outpatient Clinics: A Sign of High Residual Risk? Data from 7,105 Patients. Int J Vasc Med. 2022 Jan 6;2022:4224975. doi: 10.1155/2022/4224975. PMID: 35036009; PMCID: PMC8758294.
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Naghavi M, Kleis S, Tanaka H, Yen AA, Zhuang R, Gul A, Naghavi Y, Metcalfe R. High Frequency of Microvascular Dysfunction in US Outpatient Clinics: A Sign of High Residual Risk? Data from 7,105 Patients. Int J Vasc Med. 2022 Jan 6;2022:4224975. doi: 10.1155/2022/4224975. PMID: 35036009; PMCID: PMC8758294.
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Chen MC, Lee CJ, Lin YL, Wang CH, Hsu BG. The Association between Serum Adiponectin Levels and Endothelial Function in Non-Dialysis-Dependent Chronic Kidney Disease Patients. Biomedicines. 2023 Aug 2;11(8):2174. doi: 10.3390/biomedicines11082174. PMID: 37626670; PMCID: PMC10452815.
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Shokr H, Gherghel D. European Society of Cardiology/European Society of Hypertension versus the American College of Cardiology/American Heart Association guidelines on the cut-off values for early hypertension: a microvascular perspective. Sci Rep. 2021 Feb 10;11(1):3473. doi: 10.1038/s41598-021-83096-1. PMID: 33568754; PMCID: PMC7876123.
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Arce-Esquivel, Arturo A.; Ballard, Joyce E. FACSM; Haas, Barbara K.; Hermanns, Melinda L.; Kimmel, Gary T.; Wang, Yong T. FACSM. Effect of Tai Chi on Vascular Function Among Peripheral Neuropathy Patients: 715 Board #31 June 1, 3. Medicine & Science in Sports & Exercise 48(5S):p 192, May 2016. | DOI: 10.1249/01.mss.0000485578.00349.cd.
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Lin HH, Ho CC, Chen YC, Ho GJ, Hsu BG, Lee MC. Serum myostatin level is a positive predictor of endothelial function measured by digital thermal monitoring of vascular reactivity in kidney transplantation patients. Tzu Chi Med J. 2021 Apr 1;34(1):62-68. doi: 10.4103/tcmj.tcmj_268_20. PMID: 35233358; PMCID: PMC8830547.
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Karimzad S, Shokr H, Bellary S, Singhal R, Gherghel D. The Effect of Bariatric Surgery on Microvascular Structure and Function, Peripheral Pressure Waveform and General Cardiovascular Risk: A Longitudinal Study. J Clin Med. 2023 Nov 28;12(23):7379. doi: 10.3390/jcm12237379. PMID: 38068431; PMCID: PMC10707558.​
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Karimzad SE, Shokr H, Gherghel D. Retinal and peripheral vascular function in healthy individuals with low cardiovascular risk. Microvasc Res. 2019 Nov;126:103908. doi: 10.1016/j.mvr.2019.103908. Epub 2019 Jul 31. PMID: 31376402.
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Fan HJ, Wang CH, Hsu BG, Tsai JP. Association between Serum Adipocyte Fatty Acid Binding Protein Level and Endothelial Dysfunction in Chronic Hemodialysis Patients. Life (Basel). 2022 Feb 20;12(2):316. doi: 10.3390/life12020316. PMID: 35207603; PMCID: PMC8878502.
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Munasingha SC, Keerthi Priyankara K, Liyanagoonawardena SN, Vithanage Charith W, Pinto CS, Wickremasinghe K, Constantine GR, Jayasinghe S. A Hybrid Approach for Screening Endothelial Dysfunction using Photoplethysmography and Digital Thermal Monitoring. Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:734-739. doi: 10.1109/EMBC46164.2021.9629748. PMID: 34891396.​
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Lin WC, Lee MC, Hsu BG. Positive Association of Serum Adiponectin Level With the Vascular Reactivity Index in Kidney Transplant Patients. Exp Clin Transplant. 2021 Dec;19(12):1271-1276. doi: 10.6002/ect.2021.0253. Epub 2021 Nov 11. PMID: 34775936.
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Hsu BG, Wang CH, Lai YH, Tsai JP. Serum Galectin-3 Level Is Positively Associated with Endothelial Dysfunction in Patients with Chronic Kidney Disease Stage 3 to 5. Toxins (Basel). 2021 Jul 29;13(8):532. doi: 10.3390/toxins13080532. PMID: 34437403; PMCID: PMC8402460.
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Abdulhai F, Jaffa MA, Elias J, Zakka P, Hotait M, Bou-Fakhredin R, Arnaout S, Taher AT, Refaat MM. Digital thermography and vascular involvement in β-thalassemia intermedia. Ann Hematol. 2021 Oct;100(10):2471-2477. doi: 10.1007/s00277-021-04588-8. Epub 2021 Jul 8. PMID: 34235558.
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You AS, Budoff M, Zeb I, Ahmadi N, Novoa A, Flores F, Hamal S, Kinninger A, Dailing C, Nakata T, Kovesdy CP, Nguyen DV, Brent GA, Kalantar-Zadeh K, Rhee CM. Elevated serum thyrotropin levels and endothelial dysfunction in a prospective hemodialysis cohort. Hemodial Int. 2022 Jan;26(1):57-65. doi: 10.1111/hdi.12964. Epub 2021 Jul 6. PMID: 34231302; PMCID: PMC10753993.
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Do V, Eckersley L, Lin L, Davidge ST, Stickland MK, Ojala T, Serrano-Lomelin J, Hornberger LK. Persistent Aortic Stiffness and Left Ventricular Hypertrophy in Children of Diabetic Mothers. CJC Open. 2020 Nov 13;3(3):345-353. doi: 10.1016/j.cjco.2020.10.020. PMID: 33778451; PMCID: PMC7985002.
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Frech TM, Ou Z, Presson AP. Clinical Bedside Tools to Assess Systemic Sclerosis Vasculopathy: Can Digital Thermal Monitoring and Sublingual Microscopy Identify Patients With Digital Ulcers? J Rheumatol. 2021 Oct;48(10):1566-1568. doi: 10.3899/jrheum.201234. Epub 2021 Feb 1. PMID: 33526620; PMCID: PMC8325717.
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Ali A, Uribe C, Araujo-Gutierrez R, Cruz-Solbes AS, Marcos-Abdala HG, Youker KA, Guha A, Torre-Amione G, Nguyen DT, Graviss EA, Cooke JP, Bhimaraj A. Endothelial Dysfunction-related Neurological Bleeds with Continuous Flow-Left Ventricular Assist Devices Measured by Digital Thermal Monitor. ASAIO J. 2021 May 1;67(5):561-566. doi: 10.1097/MAT.0000000000001281. PMID: 33074858.
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Lin L, Chiu LT, Lee MC, Hsu BG. Serum Osteocalcin Level is Negatively Associated with Vascular Reactivity Index by Digital Thermal Monitoring in Kidney Transplant Recipients. Medicina (Kaunas). 2020 Aug 9;56(8):400. doi: 10.3390/medicina56080400. PMID: 32784817; PMCID: PMC7466333.
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Thomas JK, Radic M, Tucker JR, Overbury R, Frech TM. Raynaud Phenomenon in Systemic Sclerosis: Does Digital Thermal Monitoring Correlate to Specific Nailfold Videocapillaroscopy Abnormalities? J Rheumatol. 2021 Feb;48(2):247-250. doi: 10.3899/jrheum.191371. Epub 2020 Jun 15. PMID: 32541075; PMCID: PMC7736231.
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Mogadam E, King K, Shriner K, Chu K, Sondergaard A, Young K, Naghavi M, Kloner RA. The association of nadir CD4-T cell count and endothelial dysfunction in a healthy HIV cohort without major cardiovascular risk factors. SAGE Open Med. 2020 May 26;8:2050312120924892. doi: 10.1177/2050312120924892. PMID: 32537154; PMCID: PMC7268551.
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Wang CH, Lai YH, Kuo CH, Lin YL, Tsai JP, Hsu BG. Association between Serum Indoxyl Sulfate Levels and Endothelial Function in Non-Dialysis Chronic Kidney Disease. Toxins (Basel). 2019 Oct 11;11(10):589. doi: 10.3390/toxins11100589. PMID: 31614554; PMCID: PMC6832597.
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Frech TM, Murtaugh MA. Non-invasive digital thermal monitoring and flow-mediated dilation in systemic sclerosis. Clin Exp Rheumatol. 2019 Jul-Aug;37 Suppl 119(4):97-101. Epub 2019 Sep 17. PMID: 31573479; PMCID: PMC7153574.
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Chen TL, Lee MC, Ho CC, Hsu BG, Tsai JP. Serum Adipocyte Fatty Acid-Binding Protein Level is Negatively Associated with Vascular Reactivity Index Measured by Digital Thermal Monitoring in Kidney Transplant Patients. Metabolites. 2019 Jul 31;9(8):159. doi: 10.3390/metabo9080159. PMID: 31370219; PMCID: PMC6724141.
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van der Heijden DJ, van Leeuwen MAH, Janssens GN, Lenzen MJ, van de Ven PM, Eringa EC, van Royen N. Body Mass Index Is Associated With Microvascular Endothelial Dysfunction in Patients With Treated Metabolic Risk Factors and Suspected Coronary Artery Disease. J Am Heart Assoc. 2017 Sep 14;6(9):e006082. doi: 10.1161/JAHA.117.006082. PMID: 28912211; PMCID: PMC5634274.
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Wang X, Li X, Chu X, Dong Q, Zhao X, Chen H, Zhang K. [Study on Relationship between Assessment of Vascular Function Using Digital Fingertip Thermal Monitoring and Pulse Wave Velocity]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2016 Dec;33(6):1084-9. Chinese. PMID: 29714971.
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Naghavi M, Yen AA, Lin AW, Tanaka H, Kleis S. New Indices of Endothelial Function Measured by Digital Thermal Monitoring of Vascular Reactivity: Data from 6084 Patients Registry. Int J Vasc Med. 2016;2016:1348028. doi: 10.1155/2016/1348028. Epub 2016 Oct 18. PMID: 27830091; PMCID: PMC5088311.
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Frolow M, Drozdz A, Kowalewska A, Nizankowski R, Chlopicki S. Comprehensive assessment of vascular health in patients; towards endothelium-guided therapy. Pharmacol Rep. 2015 Aug;67(4):786-92. doi: 10.1016/j.pharep.2015.05.010. Epub 2015 Jun 3. PMID: 26321282.
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Schier R, Schick V, Amsbaugh A, Aguilar J, Hernandez M, Mehran RJ, Riedel B, Hinkelbein J. Brachial artery reactivity and vascular reactive hyperemia for preoperative anaesthesia risk assessment - an observational study. BMC Anesthesiol. 2014 Jun 21;14:47. doi: 10.1186/1471-2253-14-47. PMID: 24971042; PMCID: PMC4071153.
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Schier R, Hinkelbein J, Marcus H, Smallwood A, Correa AM, Mehran R, El-Zein R, Riedel B. A novel technique for the assessment of preoperative cardiovascular risk: reactive hyperemic response to short-term exercise. Biomed Res Int. 2013;2013:837130. doi: 10.1155/2013/837130. Epub 2013 Apr 10. PMID: 23691513; PMCID: PMC3652140.
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Schier R, Marcus HE, Mansur E, Lei X, El-Zein R, Mehran R, Purugganan R, Heir JS, Riedel B, Gottumukkala V. Evaluation of digital thermal monitoring as a tool to assess perioperative vascular reactivity. J Atheroscler Thromb. 2013;20(3):277-86. doi: 10.5551/jat.15255. Epub 2012 Nov 29. PMID: 23197179.
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Shao H, He Y, Mu L. Numerical analysis of dynamic temperature in response to different levels of reactive hyperaemia in a three-dimensional image-based hand model. Comput Methods Biomech Biomed Engin. 2014;17(8):865-74. doi: 10.1080/10255842.2012.723698. Epub 2012 Sep 21. PMID: 22994164.
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Zeb I, Ahmadi N, Molnar MZ, Li D, Shantouf R, Hatamizadeh P, Choi T, Kalantar-Zadeh K, Budoff MJ. Association of coronary artery calcium score and vascular dysfunction in long-term hemodialysis patients. Hemodial Int. 2013 Apr;17(2):216-22. doi: 10.1111/j.1542-4758.2012.00739.x. Epub 2012 Sep 11. PMID: 22962941; PMCID: PMC4319179.
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Larijani VN, Ahmadi N, Zeb I, Khan F, Flores F, Budoff M. Beneficial effects of aged garlic extract and coenzyme Q10 on vascular elasticity and endothelial function: the FAITH randomized clinical trial. Nutrition. 2013 Jan;29(1):71-5. doi: 10.1016/j.nut.2012.03.016. Epub 2012 Aug 2. PMID: 22858191; PMCID: PMC4277702.
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Ahmadi N, McQuilkin GL, Akhtar MW, Hajsadeghi F, Kleis SJ, Hecht H, Naghavi M, Budoff M. Reproducibility and variability of digital thermal monitoring of vascular reactivity. Clin Physiol Funct Imaging. 2011 Nov;31(6):422-8. doi: 10.1111/j.1475-097X.2011.01037.x. Epub 2011 Jul 3. PMID: 21981452.
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Akhtar MW, Kleis SJ, Metcalfe RW, Naghavi M. Sensitivity of digital thermal monitoring parameters to reactive hyperemia. J Biomech Eng. 2010 May;132(5):051005. doi: 10.1115/1.4001137. PMID: 20459206.
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Schwartz BG, Economides C, Mayeda GS, Burstein S, Kloner RA. The endothelial cell in health and disease: its function, dysfunction, measurement and therapy. Int J Impot Res. 2010 Mar-Apr;22(2):77-90. doi: 10.1038/ijir.2009.59. Epub 2009 Dec 24. PMID: 20032988.
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van der Wall EE, Schuijf JD, Bax JJ, Jukema JW, Schalij MJ. Fingertip digital thermal monitoring: a fingerprint for cardiovascular disease? Int J Cardiovasc Imaging. 2010 Feb;26(2):249-52. doi: 10.1007/s10554-009-9552-0. Epub 2009 Dec 12. PMID: 20012695; PMCID: PMC2817076.
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McQuilkin GL, Panthagani D, Metcalfe RW, Hassan H, Yen AA, Naghavi M, Hartley CJ. Digital thermal monitoring (DTM) of vascular reactivity closely correlates with Doppler flow velocity. Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:1100-3. doi: 10.1109/IEMBS.2009.5333962. PMID: 19964497; PMCID: PMC3341617.
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Ahmadi N, Hajsadeghi F, Gul K, Leibfried M, DeMoss D, Lee R, Flores F, Nasir K, Hecht H, Naghavi M, Budoff MJ. Vascular function measured by fingertip thermal reactivity is impaired in patients with metabolic syndrome and diabetes mellitus. J Clin Hypertens (Greenwich). 2009 Nov;11(11):678-84. doi: 10.1111/j.1559-4572.2009.00058.x. PMID: 19878383; PMCID: PMC8673197.
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Ahmadi N, Nabavi V, Nuguri V, Hajsadeghi F, Flores F, Akhtar M, Kleis S, Hecht H, Naghavi M, Budoff M. Low fingertip temperature rebound measured by digital thermal monitoring strongly correlates with the presence and extent of coronary artery disease diagnosed by 64-slice multi-detector computed tomography. Int J Cardiovasc Imaging. 2009 Oct;25(7):725-38. doi: 10.1007/s10554-009-9476-8. Epub 2009 Jul 26. PMID: 19634001; PMCID: PMC2729419.
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Budoff MJ, Ahmadi N, Gul KM, Liu ST, Flores FR, Tiano J, Takasu J, Miller E, Tsimikas S. Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial. Prev Med. 2009 Aug-Sep;49(2-3):101-7. doi: 10.1016/j.ypmed.2009.06.018. Epub 2009 Jun 30. PMID: 19573556.
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Gul KM, Ahmadi N, Wang Z, Jamieson C, Nasir K, Metcalfe R, Hecht HS, Hartley CJ, Naghavi M. Digital thermal monitoring of vascular function: a novel tool to improve cardiovascular risk assessment. Vasc Med. 2009 May;14(2):143-8. doi: 10.1177/1358863X08098850. PMID: 19366821; PMCID: PMC3349085.
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Ahmadi N, Usman N, Shim J, Nuguri V, Vasinrapee P, Hajsadeghi F, Wang Z, Foster GP, Nasir K, Hecht H, Naghavi M, Budoff M. Vascular dysfunction measured by fingertip thermal monitoring is associated with the extent of myocardial perfusion defect. J Nucl Cardiol. 2009 May-Jun;16(3):431-9. doi: 10.1007/s12350-008-9044-y. Epub 2009 Jan 6. PMID: 19125310.
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Ahmadi N, Hajsadeghi F, Gul K, Vane J, Usman N, Flores F, Nasir K, Hecht H, Naghavi M, Budoff M. Relations between digital thermal monitoring of vascular function, the Framingham risk score, and coronary artery calcium score. J Cardiovasc Comput Tomogr. 2008 Nov;2(6):382-8. doi: 10.1016/j.jcct.2008.09.001. Epub 2008 Sep 26. PMID: 19083982.​​
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