Have you heard of “Endothelial Resilience”?
Arterioscler Thromb Vasc Biol 2020 Oct 22
Exploring the Role of Endothelial Cell Resilience in Cardiovascular Health and Disease Yunling Gao 1, Zorina S Galis 1
• 1 • From the Division of Cardiovascular Sciences, Vascular Biology and Hypertension Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD. • PMID: 33086867 DOI: 10.1161/ATVBAHA.120.314346
Abstract Traditionally, much research effort has been invested into focusing on disease, understanding pathogenic mechanisms, identifying risk factors, and developing effective treatments. A few recent studies unraveling the basis for absence of disease, including cardiovascular disease, despite existing risk factors, a phenomenon commonly known as resilience, are adding new knowledge and suggesting novel therapeutic approaches. Given the central role of endothelial function in cardiovascular health, we herein provide a number of considerations that warrant future research and considering a paradigm shift toward identifying the molecular underpinnings of endothelial resilience. Keywords: COVID-19; cardiovascular disease; endothelial cells; nitric oxide; vascular endothelium.
Correspondence to: Yunling Gao, PhD, Division of Cardiovascular Sciences, Vascular Biology and Hypertension Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 6705 Rockledge Dr, Bethesda, MD 20817. Email email@example.com
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