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Women with Premature MI Linked to Persistent Endothelial Dysfunction in Pregnancy.

Int J Cardiol. 2016 May 21;219:9-13.

Premature cardiovascular disease following a history of hypertensive disorder of pregnancy.

McDonald EG1, Dayan N2, Pelletier R3, Eisenberg MJ4, Pilote L2.

1Division of General Internal Medicine, Department of Medicine, McGill University Health Centre, Montreal, Canada. 2Division of General Internal Medicine, Department of Medicine, McGill University Health Centre, Montreal, Canada. 3Division of Clinical Epidemiology, McGill University Health Centre, Montréal, Québec. 4Division of Cardiology, Department of Medicine, McGill University, Canada.


In this study of women with premature cardiovascular disease, ST-elevation myocardial infarction was associated with a history of preeclampsia possibly because of persistent endothelial dysfunction. High-risk coronary lesions on angiography did not appear to have an association with preeclampsia or gestational hypertension despite a high burden of traditional risk factors.

Ultrasound Obstet Gynecol. 2016

Endothelial dysfunction in women with a previous pre-eclampsia.

Orabona R1, Sciatti E2, Vizzardi E2, Bonadei I2, Valcamonico A1, Metra M2, Frusca T1,3.

  • 1Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology, University of Brescia, Italy.

  • 2Section of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Italy.

  • 3Department of Obstetrics and Gynecology, University of Parma, Italy.


Women with previous pregnancies complicated by pre-eclampsia, in particular cases with early-onset of the disease, showed a persistent microcirculatory dysfunction, as suggested by a significant reduction of reactive hyperaemia index value, and an increased arterial stiffness.

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