patients without clinically manifest arterial diseases
M Rossi 1, A Carpi, C Di Maria, F Franzoni, F Galetta, G Santoro Affiliations expand
Abstract Fourier spectral analysis of forearm skin laser Doppler flowmetry (LDF) signal was performed in fifteen hypercholesterolemic patients (HP), without clinically manifest arterial diseases, and in fifteen age-matched healthy control subjects (CS), in order to investigate skin blood flowmotion (SBF). The LDF frequency intervals studied were: 0.01-1.6 Hz total spectrum, as well as 0.01-0.02 Hz (endothelial), 0.02-0.06 Hz (sympathetic), 0.06-0.2 Hz (myogenic), 0.2-0.6 Hz (respiratory) and 0.6-1.6 Hz (cardiac). Skin microvascular reactivity (MVR) to acetylcholine (ACh) and to sodium nitroprusside (SNP) iontophoresis was also investigated. HP showed a lower post-ACh increase in power spectral density (PSD) of the 0.01-0.02 Hz SBF subinterval compared to CS (1.80+/-1.73 PU(2)/Hz vs 3.59+/-1.78 PU(2)/Hz, respectively; p<0.005), while they did not differ in MVR from CS. In eleven HP the 0.01-0.02 Hz SBF subinterval showed a higher post-ACh PSD increase near to the statistical significance after 10 weeks of rosuvastatin therapy (10 mg/day) compared to pretreatment test (3.04+/-2.95 PU(2)/Hz vs 1.91+/-1.94 PU(2)/Hz; p=0.07). The blunted post-ACh increase in PSD of the 0.01-0.02 Hz SBF subinterval in HP suggests a skin endothelial dysfunction in these patients. This SBF abnormality showed a tendency to improve after rosuvastatin therapy in eleven treated patients.
Blunted increase of digital skin vasomotion following acetylcholine and sodium nitroprusside iontophoresis in systemic sclerosis patients.Rossi M, Bazzichi L, Di Maria C, Franzoni F, Raimo K, Della Rossa A, Santoro G, Bombardieri S.Rheumatology (Oxford). 2008 Jul;47(7):1012-7. doi: 10.1093/rheumatology/ken117. Epub 2008 Apr 22.PMID: 18430760
Blunted post-ischemic increase of the endothelial skin blood flowmotion component as early sign of endothelial dysfunction in chronic kidney disease patients.Rossi M, Cupisti A, Di Maria C, Galetta F, Barsotti G, Santoro G.Microvasc Res. 2008 Apr;75(3):315-22. doi: 10.1016/j.mvr.2007.08.002. Epub 2007 Aug 24.PMID: 17931669
Absent post-ischemic increase of blood flowmotion in the cutaneous microcirculation of healthy chronic cigarette smokers.Rossi M, Carpi A, Di Maria C, Galetta F, Santoro G.Clin Hemorheol Microcirc. 2007;36(2):163-71.PMID: 17325440
Current concepts in assessment of microvascular endothelial function using laser Doppler imaging and iontophoresis.Turner J, Belch JJ, Khan F.Trends Cardiovasc Med. 2008 May;18(4):109-16. doi: 10.1016/j.tcm.2008.02.001.PMID: 18555183 Review.
Methodological issues in the assessment of skin microvascular endothelial function in humans.Cracowski JL, Minson CT, Salvat-Melis M, Halliwill JR.Trends Pharmacol Sci. 2006 Sep;27(9):503-8. doi: 10.1016/j.tips.2006.07.008. Epub 2006 Jul 31.PMID: 16876881 Review.
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